| p21、p185、p53蛋白表达对卵巢交界性浆液性肿瘤的鉴别诊断价值 |
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| 引用本文： | 王嘉莉. p21、p185、p53蛋白表达对卵巢交界性浆液性肿瘤的鉴别诊断价值[J]. 河南医学研究, 1999, 8(3): 216-217 |
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| 作者姓名： | 王嘉莉 |
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| 作者单位： | 河南省肿瘤医院!郑州450003(王嘉莉，成慧君)，河南中医学院第一附属医院(邱王番) |
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| 摘 要： | 目的： 探讨ｒａｓ、ｃ ｅｒｂＢ ２、ｐ５３ 基因产物ｐ２１ 、ｐ１８５ 、ｐ５３ 蛋白表达对卵巢浆液性肿瘤中良性瘤、交界性瘤和癌的鉴别诊断价值。方法： 采用ＬＳＡＢ免疫组化法。结果：３ 种蛋白在良性瘤、交界性瘤和癌中的单一表达均呈递增趋势，差异显著；联合表达，２ 种以上蛋白同时阳性率后两组高于良性瘤组，差异显著，Ｐ＜ ０００５ ；３ 种蛋白同时阳性率癌组高于前两组，差异显著，Ｐ＜ ００５ 。结论：３ 种蛋白的表达可以作为卵巢浆液性肿瘤中良性瘤、交界性瘤和癌的鉴别诊断的客观指标。
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| 关 键 词： | 卵巢交界性浆液性囊腺瘤 p21、p185、p53蛋白 鉴别诊断 |
The differential diagnosis value of expression of p21,p185 and p53 proteins in ovarian borderline serous tumor |
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| Wang Jiali Cheng Huijun Qiu Fan. The differential diagnosis value of expression of p21,p185 and p53 proteins in ovarian borderline serous tumor[J]. Henan Medical Research, 1999, 8(3): 216-217 |
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| Authors: | Wang Jiali Cheng Huijun Qiu Fan |
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| Abstract: | Objective: To explore the differential diagnosis value of expression of p21,p185,p53 proteins in ovarian serous tumors.Methods: Using LSAB immunohistochemical technique Results: Positive expression percent of the three proteins increased in benign,borderline and malignant tumors,the difference was significant, P <0 05.The combined expression percent increased in three tumors.For more than two proteins positive in a patient,the behind two tumors were higher than the benign tumor;For three proteins positive in a patient,the malignant tumor was higher than the others.Conclusion: the expression of these three proteins is an object parameter in differential diagnosis of ovarian borderline tumors. |
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| Keywords: | ovarian borderline serous tumors p21 p53 p185 proteins differential diagnosis |
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