VEGF在不同类型子痫前期患者胎盘组织中的表达及意义

目的探讨血管内皮生长因子（VEGF）在不同类型子痫前期患者胎盘组织中的表达及意义。方法采用免疫组织化学SP法检测18例正常孕妇（对照组），36例子痫前期患者（子痫前期组，其中轻度子痫前期患者18例，重度子痫前期患者18例）胎盘组织中VEGF的表达强度。结果VEGF主要表达于胎盘绒毛滋养细胞；重度子痫前期患者胎盘绒毛滋养细胞VEGF表达强度明显低于对照组及轻度子痫前期患者（P＜0．05），而轻度子痫前期患者与对照组比较，无显著性差异（P＞0．05）。结论VEGF在胎盘中主要由绒毛滋养细胞分泌，子痫前期患者VEGF分泌减少，尤其是重度子痫前期的患者,这可能是引起局部胎盘绒毛及血管痛变的原因。

Expression and significance of vascular endothelial growth factor in placenta from pregnancy complicated with pre- eclampsia

Objective: To study the expression of vascular endothelial growth factor(VEGF) in placenta from normal pregnancy and pregnancy complicated with pre-eclampsia and the significance of VEGF on the etiology of pre-eclampsia.Methods:Use the immunohistochemistry to determine the intensity of VEGF staining in placenta from 18 cases of normal pregnancy and 36 cases of pregnancies complicated with mild,severe group pre-eclampsia.Results:Immunolocalization of VEGF in all cases was observed mainly in syncytiotrophoblast.Intensity of VEGF immnostaining in syncytiotrophoblast was significantly reduced in the severe pre-eclampsia group(P<0.05= compared with both the mild pre-eclampsia group and the normal group,while there was no qualitative differences between the mild pre-eclampsia group and the normal group(P>0.05).Conclusion:These results suggest that VEGF is secreted mainly by syncytiotrophoblast in human placenta and the reduced VEGF may be responsible,at least in part,for the impaired vascular development in pre-eclampsia.