| 疫苗接种预防小鼠柯萨奇B_(3ro)病毒心肌炎的初步研究 |
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| 引用本文： | 陈晓敏,陈曙霞,钱富荣,刘晶星,陆德源,姚季生,姚申. 疫苗接种预防小鼠柯萨奇B_(3ro)病毒心肌炎的初步研究[J]. 现代免疫学, 1992, 0(1) |
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| 作者姓名： | 陈晓敏 陈曙霞 钱富荣 刘晶星 陆德源 姚季生 姚申 |
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| 作者单位： | 上海第二医科大学附属仁济医院，上海第二医科大学附属仁济医院，上海第二医科大学附属仁济医院，上海第二医科大学微生物教研室，上海第二医科大学微生物教研室，上海第二医科大学法医教研室，上海第二医科大学法医教研室 上海 200001 浙江宁波第一医院内科，315010，上海 200001，上海 200001，上海 200001，上海 200001，上海 200001，上海 200001 |
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| 摘 要： | 用1:4000甲醛灭活的COXB_(3m)病毒制成疫苗,用以皮下注射BALB/c小鼠,共2次,间隔7天。结果发现,小鼠的血清中和抗体均转阳性,抗体滴度平均为98.49±2.08,而对照组小鼠的血清中和抗体均为阴性,两组差别显著(p<0.001)。第2次疫苗接种后14天,以COXB_(3m)病毒经腹腔攻击小鼠,结果显示,免疫组动物死亡率为10%(1/10),而对照组为70%(7/10),两组差别显著(p<0.005)。组织病理检查发现,对照组小鼠心肌有灶性坏死和少量小单核细胞浸润,而免疫组动物心脏未见明显病变。
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PRELIMINARY STUDY ON VIRUS VACCINATION FOR THE PREVENTION OF VIRAL MYOCARDITIS IN MICE |
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| Abstract: | BALB/c mice were vaccinated with formalin-inactivated coxsackie B3m virus va ccine subcutaneously once a week for two times. Fourteen days after the second vaccination, neutralizing antibody titer was 98.49±2.68 in vaccinated mice. Neutralizing antibody was negative in the control mice. The difference between two groups was very significant(p<0.001). Two weeks after the second vaccination, both groups of mice were challenged with coxsackie B3m virus intraperitoneally. The mortality of vaccinated group and control group were 10% and 70%respectively (p<0.005). Histologically, focal myocardial necrosis and mononuclear cell infiltration were found in the heart muscles of control mice, whereas no histologie abnormalities were found in. those of vaccinated mice. |
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