Combined arsenic trioxide and all-trans retinoic acid treatment for acute promyelocytic leukaemia recurring from previous relapses successfully treated using arsenic trioxide |
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Authors: | Au W Y Chim C S Lie A K W Liang R Kwong Y L |
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Affiliation: | University Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong. |
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Abstract: | The optimal treatment of acute promyelocytic leukaemia (APL) recurring from relapses successfully treated using arsenic trioxide (As2O3) is undefined. Three APL patients relapsing from As2O3-induced remission were studied. Re-treatment with As2O3 failed in one patient in third relapse, and resulted in morphological but not molecular remission in another patient. Combination therapy with As2O3 and all-trans retinoic acid (ATRA), however, resulted in morphological and molecular remission in all three cases, with a follow-up time ranging from 6 to 16 months. Our results suggest a synergistic therapeutic effect between As2O3 and ATRA in APL in advanced relapse. |
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Keywords: | relapsed APL arsenic trioxide all-trans retinoic acid |
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