| 山莨菪碱对低密度脂蛋白受体再循环的影响 |
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| 引用本文： | 单茵,富丽琴,楼定安,张骅,毛峥嵘.山莨菪碱对低密度脂蛋白受体再循环的影响[J].浙江大学学报(医学版),1998(5). |
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| 作者姓名： | 单茵 富丽琴 楼定安 张骅 毛峥嵘 |
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| 作者单位： | 浙江医科大学病理教研室 |
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| 摘 要： | 目的：观察山莨菪碱对低密度脂蛋白受体再循环的影响。方法：应用抗免低密度脂蛋白受体（LDL－R）单克隆抗体，以细胞ELISA法测定成纤维细胞LDL－R，并观察蛋白合成受抑制时山莨菪碱对LDL受体的影响。结果：细胞生长汇合成单层时加入亚胺环己酮．受体无明显减少，加入山莨菪碱则细胞表面受体增加；细胞生长呈不全汇合状态时，亚胺环己酮使受体减少，但山莨菪碱对受体数无明显影响。结论：山莨菪碱具有促进生长汇合的成纤维细胞LDL－R再循环的作用。
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| 关 键 词： | 山莨菪碱／药理学 脂蛋白受体 脂蛋白类.LDL 受体再循环 |
The Effect of Anisodamine on the Recycling of Low Density Lipoprotein Receptor |
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| Shan Zhiyin, Fu Liqin, Lou Dingan,et al.The Effect of Anisodamine on the Recycling of Low Density Lipoprotein Receptor[J].Journal of Zhejiang University(Medical Sciences),1998(5). |
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| Authors: | Shan Zhiyin Fu Liqin Lou Dingan |
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| Abstract: | Objective To observe the effect of anisoclamine on recycling of low density lipoprotein receptor(LDL-R). Methods: Monoclonal anti-rabbit LDL-R antibody and cell-enzyme-linked immunoassay were used tostudy the LDL-R of rabbit fibroblast and the effect of anisedamine of LDL-R,when the protein synthesis was inhibited. Results: When cells were cultured in confluent monolayer, the LDL-R was increased in the presence ofanisodamine but not in the presence of cycloheximide. When cells were in hemiconfluent culture,the LDL-R wasdecreased by cycloheximide but not by anisodamine. Conclusion: Anisodamine can promote LDL-R recycling ofcultured fibroblasts in confluent monolayer. |
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| Keywords: | Anisedamine/pharmacol Lipoprotein recepter Liporoteins LDL Receptor recycling |
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