Parallelism between oestrogen binding capacity and hormone responsiveness of mammary tumours in GR-A mice |
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| Authors: | L Terenius |
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| Affiliation: | 1. Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing 100730, China.;2. Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing 100730, China.;1. Department of Neurology, The Second Hospital of Hebei Medical University, No. 215 Heping West Road, Shijiazhuang, Hebei 050000, China;2. Beijing Geriatric Healthcare Center, Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, Xicheng District, Beijing 100053, China;3. Xiangya School of Medicine, Central South University, No.172 Tongzipo Road, Changsha, Hunan 410013, China;4. Department of Geriatrics, The Second Hospital of Hebei Medical University, No. 215 Heping West Road, Shijiazhuang, Hebei 050000, China;5. Beijing Municipal Geriatric Medical Research Center, No. 45 Changchun Street, Xicheng District, Beijing 100053, China |
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| Abstract: | Mammary tumours arise in the GR/A-mouse strain at pregnancy. Such tumours are initially pregnancy-dependent, i.e. regress after parturition. The tumours undergo progression: at subsequent pregnancies postpartum regression becomes less complete and finally growth is independent of hormones.The content of oestrogen ‘receptors’ in pregnancy-dependent and independent tumours of GR/A-mice has been determined. It was found that the dependent and non-regressing tumours contained such receptors while the independent tumours had low levels or absence of receptors.The parallel loss of oestrogen receptors and hormone dependence suggest that oestrogens play a role for growth and control at the dependent stage. |
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