| 补肾密骨液对大鼠卵巢切除诱导的实验性骨质疏松症的影响 |
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| 引用本文： | 杜靖远,沈霖.补肾密骨液对大鼠卵巢切除诱导的实验性骨质疏松症的影响[J].中华骨科杂志,1996,16(7):462-464. |
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| 作者姓名： | 杜靖远 沈霖 |
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| 作者单位： | 同济医科大学附属协和医院骨科 |
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| 摘 要： | 运用骨组织形态计量学观察了中药补肾密骨液对大鼠切除卵巢诱导的实验性骨质疏松症模型的影响，并与防治骨质疏松药尼尔雌醇及生理盐水进行对照．结果显示，中药组及尼尔雌醇组骨小梁密度显著高于盐水组，破骨细胞指数明显低于盐水组（Ｐ值＜０．０５）．在类骨质含量及骨形成参数值测量中，中药组明显高于尼尔雌醇及盐水组（Ｐ值＜０．０５）．提示：补肾密骨液不仅能抑制破骨细胞的骨吸收活动，还能增生成骨细胞，产生较多的骨基质，使模鼠的骨代谢恢复正态平衡．
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| 关 键 词： | 补肾密骨液 骨质疏松症 骨组织计量学 卵巢切除术 大鼠 |
EffectofBushenMiguYeonOsteoporosisInducedbyOvariectomy:AnExperimentalStudy |
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| DuJingyuan,ShenLin,YanJiayu,et al..EffectofBushenMiguYeonOsteoporosisInducedbyOvariectomy:AnExperimentalStudy[J].Chinese Journal of Orthopaedics,1996,16(7):462-464. |
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| Authors: | DuJingyuan ShenLin YanJiayu |
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| Institution: | DuJingyuan,ShenLin,YanJiayu,etal.UnionHospital,TongjiMedicalUniversity,Wuhan430022 |
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| Abstract: | HistomorphometricmeasurementwasusedtoobservetheeffectofBushenMiguYe(BSMGY)-amixtureofChineseherbmedicineonosteoporosisinratsfolowingovariectomy.48ani-malswererandomlydividedinto4groups.Thecontrolgroupwasgivennothingfolowingovariectomyfortheobservationofthedevelopmentofosteoporosis.Theexperimentalgroupswererespectivelygiv-enBSMGY,Nilestriol(NLST)andnormalsaline(NS)folowingsurgeryforthecomparativestudyoftheirefectonosteoporosis.AnalysisofthedatashowedthatthetrabeculardensityofthegroupsgivenBSMGYandNLSTwerehigherandtheosteoclasticindiceswerelowerthanthatofthegroupgivenNS(P<0.05).TheparametersrelatedtoboneformationandosteoidcontentinthegroupgivenBSMGYweresignificantlyhigherthanthatobservedintheNLSTandNSgroups(P<0.05).ThispreliminarystudysuggestedthatBSMGYisabletoinhibitboneresorptionactivityofosteoclastsandalsotoin-creasethenumberofosteoblaststoproducemoreosteoidandthusenhancingtherecoveryofpositivebalanceonthecancelousboneremodelingintheosteoporosismodel. |
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| Keywords: | HistomorphometricmeasurementOsteoporosisOvariectomy |
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