| 血浆GSTP1和SFRP1基因甲基化分析在肝细胞癌早期诊断中的价值 |
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| 引用本文： | 王丰,华东,吴玉玉,程之红,胡瑜,谢其根,王琼瑶,杜祥,黄朝晖.血浆GSTP1和SFRP1基因甲基化分析在肝细胞癌早期诊断中的价值[J].中国癌症杂志,2011,21(1):12-16. |
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| 作者姓名： | 王丰 华东 吴玉玉 程之红 胡瑜 谢其根 王琼瑶 杜祥 黄朝晖 |
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| 作者单位： | 1. 苏州大学附属第四医院肿瘤研究所,江苏,无锡,214062
2. 复旦大学附属肿瘤医院病理科,复旦大学上海医学院肿瘤学系,上海,200032 |
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| 摘 要： | 背景与目的:DNA甲基化是一种新的肿瘤诊断及预后判断的标志物.本研究运用自行建立的甲基化敏感性限制性内切酶一定量PCR(methylation-sensitive restriction enzymes-based quantitative PCR,MSRE-qPCR)方法检测血浆GSTP1和SFRP1基因的DNA甲基...
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| 关 键 词： | DNA甲基化 限制性内切酶 肝细胞癌 血浆 诊断 |
The clinical significance of plasma methylation analysis of GSTP1 and SFRP1 for early detection of hepatocellular carcinoma |
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| WANG Feng,HUA Dong,Wu Yu-yu,CHENG Zhi-hong,HU Yu,XIE Qi-gen,WANG Qiong-yao,DU Xiang,HUANG Zhao-hui.The clinical significance of plasma methylation analysis of GSTP1 and SFRP1 for early detection of hepatocellular carcinoma[J].China Oncology,2011,21(1):12-16. |
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| Authors: | WANG Feng HUA Dong Wu Yu-yu CHENG Zhi-hong HU Yu XIE Qi-gen WANG Qiong-yao DU Xiang HUANG Zhao-hui |
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| Institution: | WANG Feng,HUA Dong,WU Yu-yu,CHENG Zhi-hong,HU Yu,XIE Qi-gen,WANG Qiong-yao,DU Xiang,HUANG Zhao-hui(Oncology Institute,The Fourth Affiliated Hospital of Suzhou University,Wuxi Jiangsu 214062 China) |
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| Abstract: | Background and purpose:DNA methylation is a potential biomarker for tumor diagnosis and prognosis.This study aimed to detect the methylation statuses of GSTP1 and SFRP1 in plasma samples using a methylation-sensitive restriction enzymes-based quantitative PCR(MSRE-qPCR) method as well as to assess its clinical value for early noninvasive diagnosis of hepatocellular carcinoma(HCC).Methods:One hundred and fifty plasma samples from 72 patients with HCC,37 patients with a benign form of the diseases and 41 norm... |
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| Keywords: | DNA methylation Restriction enzyme Hepatocellular carcinoma Plasma Diagnosis |
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