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Sheep lung as xenograft oxygenator of human blood: An ex vivo study |
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| Authors: | M. Riquet F. LePimpec-Barthes T. Waldmann P. Nataf C. Cabrol A. Pavie D. Eme I. Gandjbakhch J. Briere D. Douguet M. Zelter |
| Affiliation: | Service de Chirurgie Thoracique, Hôpital Laennec;Service de Chirurgie Thoracique et Cardiovasculaire, Groupe Hospitalier PitièSalpètrière;Centre de Transfusion Sanguine, Hôpital Laennec;Laboratoire d'Anatomie Pathologie, Hôpital Laennec;Laboratoire de Physiologie, Faculte de Medecine Pitiè-Salpètrière, Paris, France |
| Abstract: | Abstract: In order to study whether sheep lung could be used as a suitable oxygenator for human blood, the left lungs of two groups of five sheep were used in an "isolated perfused working lung model system." A desaturator was inserted in the circuit and the lung was ventilated with ambient air. The lung was perfused in group 1 with heparinated autologous sheep blood and in group 2 with washed human erythrocytes suspended in buffered gelatin. Blood oxygenation as well as hemodynamics and airway parameters followed similar time course in both groups. |
| Keywords: | xenograft lung blood gases ex vivo model |