Additive suppressive effect of Freund's complete adjuvant on the specific inhibition of anti-DNP immunoreaction (author's transl)

Injection of DNP 38-Ficoll in 0,9 per cent saline causes a specific suppression of the secondary anti-DNP reaction in AJ-mice to the same antigen. This suppression is amplified by injection of the tolerogen in Freund's complete adjuvant (FCA) or by simultaneous injection of the tolerogen and FCA. --This additive suppressive effect of FCA is distinctly better if there are used small doses of tolerogen. Possible mechanisms interpreting these results are discussed.