血浆置换在ABO血型不相容的亲属活体肾移植中应用效果评价 |
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引用本文: | 张媛媛,应美爱,潘健,刘洪涛,刘潜,戴帅,王慧茹,刘会兰.血浆置换在ABO血型不相容的亲属活体肾移植中应用效果评价[J].临床输血与检验,2021,23(2):167-172. |
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作者姓名: | 张媛媛 应美爱 潘健 刘洪涛 刘潜 戴帅 王慧茹 刘会兰 |
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作者单位: | 230001 合肥,中国科学技术大学附属第一医院安徽省立医院 |
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基金项目: | 中央高校基本科研业务费专项资金(N o.WK9110000027)资助。 |
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摘 要: | 目的 观察血浆置换在ABO血型不相容亲属活体肾移植中清除血型抗体的临床应用效果.方法 回顾分析2017年7月~2019年1月本院54例行ABO血型不相容肾移植患者的临床特征及行血浆置换治疗后血型抗体效价变化情况,分析血浆置换治疗过程中不良反应发生情况.结果 52/54例患者血型抗体(包括IgG和IgM)效价成功降至术前...
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关 键 词: | ABO血型不相容肾移植 血浆置换 抗体滴度 |
The Clinical Effect of Plasma Exchange in ABO Incompatible Relatives in vivo Kidney Transplantation |
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Institution: | (Department of Blood Transfusion,the First Affiliated Hospital of University of Science and Technology of China,Hefei 230022) |
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Abstract: | Objective To observe the clinical effect of plasma exchange in removing blood group antibody in ABO incompatible relatives kidney transplantation.Methods The clinical characteristics of 54 cases of ABO non-identical relatives kidney transplantation in our hospital from July 2017 to January 2019 were analyzed retrospectively,and the changes of blood group antibody titer after plasma exchange treatment were analyzed.Results The titers of blood group antibodies(including IgG and IgM)were successfully reduced to the preoperative target titer in 2/54 patients,and renal transplantation was successfully carried out in 1/52 patients;One patient had the rebound titer of blood group antibody after operation,and the transplanted kidney failed.Two patients did not reduce the titer of blood group antibody to the target level.They gave up the kidney transplantation and continued the hemodialysis replacement treatment.There were 49 mild adverse events in 128 plasma exchange procedures.Conclusion Plasma exchange is an effective method to reduce the blood group antibody(including IgG and IgM)titer of recipients,which can be used in combination with other immunosuppressants to shorten the pre-operation time of patients with high blood group antibody titer. |
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Keywords: | ABO incompatible kidney transplantation Plasma exchange Antibody titer |
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