参附注射液改善心肺复苏后病人生存率的Meta分析

目的系统评价参附注射液辅助治疗对心肺复苏病人生存率的影响。方法检索MedLine、EMbase、Cochrane Library、中国生物医学文献数据库、中国知网(CNKI)、万方数据库、维普数据库,纳入参附注射液辅助治疗心肺复苏的随机对照试验(RCT),试验组应用参附注射液加常规心肺复苏治疗,对照组应用常规心肺复苏治疗,采用Cochrane Handbook 5.1.0进行质量评价与数据检测,利用RevMan 5.3进行Meta分析。结果纳入17项RCT,涉及2296例病人。心肺复苏后2 d、7 d、14 d、28 d、90 d试验组生存率明显高于对照组,差异均有统计学意义(P<0.05)。而心肺复苏后4 h、6 h、1 d、3 d两组生存率比较,差异均无统计学意义(P>0.05)。结论当前证据表明,在常规心肺复苏基础上加用参附注射液辅助治疗,能够改善心肺复苏后病人中远期(>7 d)生存率。

Shenfu Injection as an Add-on Treatment to Improve Survival Rate of Patients after Cardiopulmonary Resuscitation:a Meta-analysis

Objective To evaluate the improvement of survival rate for patients after cardiopulmonary resuscitation(CPR)by Shenfu Injection.Method Electronic databases including MedLine,EMbase,Cochrane Central Register of Controlled Trial,China Biology Medicine(CBM),China National KnowledgeInfrastructure(CNKI),Wanfang Database,and VIP Database were searched.All published randomized controlled trials(RCT)of Shenfu injection in adjuvant treatment of cardiopulmonary resuscitation were included.Cochrane Handbook 5.1.0 was used for quality assessment and data detection.The meta-analysis was performed using RevMan 5.3 software.Results Seventeen RCTs with 2296 patients were included.The survival rates in experimental group were higher than those in control group at 2 days,7 days,14 days,28 days,and 90 days after CPR(P<0.05).There was no significant difference in survival rate between two groups at 4 hours,6 hours,1 days,and 3 days(P>0.05).Conclusion Current evidence suggests that shenfu injection combined with CPR may improve medium-long term(>7 days)survival rate of the patients after CPR.