新生儿换血前后实验室指标的变化趋势

目的 探讨换血疗法对新生儿内环境造成的影响,为安全换血提供指导.方法 选取我院2016年1月～2018年12月诊断为ABO或Rh血型系统溶血病、并行换血治疗的高胆红素血症新生儿40例,分析换血治疗对患儿血常规、生化及凝血功能的影响.结果 40例患儿换血前总胆红素、直接胆红素和间接胆红素水平分别为390.4±17.98μ...

The Change of Laboratory Indexes after Exchange Transfusions for Neonates

Objective To explore the effect of exchange transfusions(ETs)on the internal environment of newborns,and to provide guidelines for safe procedure.Methods Fourty neonates were included with haemolytic disease of the foetus and newborn(HDFN)from January 2016 to December 2018.The change of blood routine examination,biochemistry and coagulation indicators were evaluated before and after ETs.Results After ETs,total bilirubin,direct bilirubin and indirect bilirubin decreased from 390.4±17.98μmol/L,18.41±1.038μmol/L and 370.4±18.16μmol/L to 271.6±12.93μmol/L,8.08±0.97μmol/L and 255.5±13.4μmol/L respectively(P<0.001);There was no significant difference in prothrombin time(PT)and activated partial thromboplastin time(APTT)(P>0.05);Red blood cells count,hemoglobin and blood glucose increased from(3.1±0.13)×10¹²/L,114.8±4.66 g/L,3.92±0.19 mmol/L to(4.58±0.11)×10¹²/L,137.3±3.18 g/L and 8.35±0.59 mmol/L respectively(P<0.001).Conclusion ETs can significantly decline the serum bilirubin level and improve clinical symptoms,but it showed some influence on some biochemical,blood routine and coagulation indexes.During and after the procedure,we should pay attention to these indexes for the safety of ETs.