BCGiosis as a presenting feature of a child with chronic granulomatous disease |
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| Authors: | Zahra Movahedi Sayna Norouzi Setareh Mamishi Nima Rezaei |
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| Institution: | 1. Fellowship of Pediatric Infectious Diseases, Pediatric Infectious Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran;2. Intern, Division of Pediatric Infectious Diseases, Children''s Medical Center, Tehran University of Medical Sciences, Tehran, Iran;3. Professor, Head of Research Center and Division of Pediatric Infectious Diseases, Pediatric Infectious Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran;4. Assistant Professor of Clinical Immunology and Executive Director of Children''s Medical Center, Molecular Immunology Research Center; and Research Center for Immunodeficiencies; Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran |
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| Abstract: | Bacillus Calmette Guerin (BCG) vaccine, which is administered to all newborns in some regions, could lead to serious complication ranging from local disease (known as BCGitis) to disseminated disease (BCGosis) in a group of patients with primary immunodeficiency diseases. We are reporting here a 3.5 year-old girl with a history of prolonged BCGitis, which developed to disseminated disease without any other special features. Immunological studies with nitro-blue tetrazolium test confirmed the diagnosis of chronic granulomatous disease in this patient. Chronic granulomatous disease should be considered in the list of differential diagnosis in all children with BCGosis, even in the absence of any other manifestations related to immunodeficiency. |
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