OCTA在区分高度近视合并早期青光眼和生理性大视杯中的应用

目的：:利用光学相干断层扫描血管成像技术（OCTA）比较高度近视合并早期原发性开角型青光眼（POAG）和生理性大视杯（LPC）的视盘、黄斑血管密度差异，探讨OCTA在区分高度近视合并早期POAG眼和高度近视合并LPC中的作用。方法：:病例对照研究。收集2019年1─12月在长沙爱尔眼科医院青光眼专科及屈光专科就诊的高度...

Differentiating Glaucoma from Physiological Optic Disc Cupping with Optical Coherence Tomography Angiography

Objective:To evaluate the ability of optical coherence tomography angiography(OCTA)for detecting large physiological disc cupping(LPC)from primary open-angle glaucoma(POAG)in highly myopic eyes.Methods:In this case control study,20 highly myopic eyes with mild primary open-angle glaucoma,22 highly myopic eyes with large disc cupping and 16 normal,non-highly myopic eyes were included.All of the patients were recruited from Changsha Aier Eye Hospital in 2019.Vessel density(VD)and retinal nerve fiber layer(RNFL)parameters were measured by OCTA.A one-way analysis of variance and Pearson coefficients were used.The areas under the receiver operating characteristic curve(AUC)were calculated.Results:The control group compared with the LPC group as follows:the RNFL thickness of the SN and IN regions was greater than that in the LPC group(all P<0.05);the VD in the deep macular layer of the entire image,including the parafovea,perifovea,and peri-N regions,were greater than that in the LPC group(all P<0.05).The LPC group compared with the POAG group as follows:the RNFL thickness of the ST,SN,IT and TI regions and the average RNFL thickness were greater than that in the POAG group(all P<0.05),the disc and peripapillary VD of the entire image,including the capillary,the entire peripapillary,and peripapillary-capillary regions,were higher than that in the POAG group(all P<0.05);the VDs of the most superficial macular regions were higher than that in the POAG group(all P<0.05).The diagnostic efficacy of the parameters between the POAG and LPC groups showed the following:The highest AUC of the disc and peripapillary disc VD was in the peripapillary-capillary region(0.90,95%CI:0.80,0.99);the AUC(0.74±0.65)of the superficial capillary density in the macular area was higher than that in the AUC(0.61±0.37)of the macular deep capillary density,and the difference was statistically significant(F=8.32,P<0.001).Conclusions:OCTA parameters can be used for early diagnosis of the differences between POAG and LPC in highly myopic eyes.