系统性红斑狼疮患者并发股骨头坏死危险因素研究

目的 探讨系统性红斑狼疮(SLE)并发股骨头坏死(ONFH)的临床特点和危险因素.方法 对我院确诊的376例SLE患者的临床及随访资料进行回顾性分析,以了解SLE合并ONFH的患病情况和危险因素.结果376例SLE股骨头坏死的发病率为7.18%(27/376),其中双侧16例(59.26%),单侧11例(40.74%);其危险因素包括口腔溃疡、雷诺氏现象、血管炎、TC、TG、累积激素用量及是否行激素冲击;在随访分析中,大剂量激素冲击治疗组患者股骨头缺血坏死终点事件的发生率显著高于非大剂量激素冲击治疗组,分别为12.50%比5.92%(P<0.05).结论 SLE患者发生股骨头坏死的危险性相对较高,血管炎、口腔溃疡、雷诺氏现象、高脂血症、激素治疗是其危险因素,尤其是大剂量糖皮质激素冲击治疗.

Risk factor of osteonecrosis of the femoral head in patients with systemic lupus erythematosus

Objective To investigate the risk factor of osteonecrosis of the femoral head (ONFH)in patients with systemic lupus erythematosus (SLE).Methods 376 patients with SLE in our hospital were enrolled in the present study.The retrospective analysis was made to investigate the risk factor of ONFH on the pathological and follow-up data.Results The incidence of ONFH in 376 SLE patients was 7.18%.Oral ulcer,Renault's phenomenon,vasculitis,osteoporosis,TC,TG,accumulated dosage of hormone and hormone intensive therapy were the risk factors of ONFH.Conclusion The incidence of ONFH in patients with SLE is relatively high,and the risk factors include Renault' s phenomenon,vasculitis,osteoporosis,TC,TG and usage of immunosuppresive treatment,especially the hormone intensive therapy with large doses.