The myelin membrane-associated enzyme 2′,3′-cyclic nucleotide 3′-phosphodiesterase:on a highway to structure and function |
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作者姓名: | Arne Raasakka, Petri Kursula |
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作者单位: | [1]Department of Biochemistry and Biocenter Oulu, University of Oulu, Oulu, Finland; [2]Department of Chemistry, University of Hamburg, Hamburg, Germany |
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基金项目: | supported by grants from the Department of Biochemistry,University of Oulu;the Sigrid Jusélius Foundation (Finland);the Academy of Finland;the Hamburg Research and Science Foundation (Germany) |
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摘 要: | The membrane-anchored myelin enzyme 2′,3′-cyclic nucleotide 3′-phosphodiesterase(CNPase) was discovered in the early 1960 s and has since then troubled scientists with its peculiar catalytic activity and high expression levels in the central nervous system. Despite decades of research, the actual physiological relevance of CNPase has only recently begun to unravel. In addition to a role in myelination, CNPase is also involved in local adenosine production in traumatic brain injury and possibly has a regulatory function in mitochondrial membrane permeabilization. Although research focusing on the CNPase phosphodiesterase activity has been helpful, several open questions concerning the protein function in vivo remain unanswered. This review is focused on past research on CNPase, especially in the fields of structural biology and enzymology, and outlines the current understanding regarding the biochemical and physiological significance of CNPase, providing ideas and directions for future research.
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关 键 词: | 磷酸二酯酶 结构生物学 环核苷酸 相关酶 磷脂膜 高速公路 中枢神经系统 创伤性脑损伤 |
收稿时间: | 2013-11-26 |
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