| 均匀设计法优选桂龙凝胶膏剂的基质处方 |
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| 引用本文： | 李智勇,邱建永,欧阳炜,王洛临,陈雪婷.均匀设计法优选桂龙凝胶膏剂的基质处方[J].广东药学,2014(10):712-715. |
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| 作者姓名： | 李智勇 邱建永 欧阳炜 王洛临 陈雪婷 |
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| 作者单位： | 广东省第二中医院,广东省中医药工程技术研究院,广东广州510405 |
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| 基金项目： | 广东省第二中医院（广东省中医药工程技术研究院）院级科研创新基金项目（编号：201204） |
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| 摘 要： | 目的优选桂龙凝胶膏剂的基质处方。方法以初黏力、持黏力和外观综合得分为指标进行综合考察,采用均匀设计法U24（247）优选桂龙凝胶膏剂的基质配方。结果桂龙凝胶膏剂基质的最佳配比为明胶∶卡波姆∶NP700∶丙二醇∶聚乙烯醇∶高岭土∶甘羟铝（3.50∶15.00∶7.74∶5.51∶0.5∶0.25∶0.03）。结论按最佳基质配方制备的桂龙凝胶膏剂具有良好的延展性,外观平整光滑,黏度适中,保湿性良好,与桂龙凝胶膏剂的浸膏粉的相容性良好。
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| 关 键 词： | 均匀设计 桂龙凝胶膏剂 基质 |
Optimization of Matrix Formulation of Guilong Cataplasm by Uniform Design |
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| LI Zhiyong,QIU Jianyong,OUYANG Wei,WANG Luolin,CHEN Xueting.Optimization of Matrix Formulation of Guilong Cataplasm by Uniform Design[J].Guangdong Pharmaceutical Journal,2014(10):712-715. |
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| Authors: | LI Zhiyong QIU Jianyong OUYANG Wei WANG Luolin CHEN Xueting |
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| Institution: | (Guangdong Second TCM Hospital, Guangdong Province Engineering Technology Research Institute of TCM, Guangzhou, Guangdong 510095, China) |
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| Abstract: | Objective To optimize the matrix formulation of Guilong cataplasm. Methods The adhesive force,cohesive strength and appearance score were used as test indexes. Uniform design U24（ 247） was used to optimize the matrix cataplasm formula. Results The best matrix cataplasm ratio was Gelatin ︰ carbomer ︰ NP 700 ︰ propylene glycol ︰ PVA ︰ kaolin︰Gan aluminum hydroxyl =3.50∶15.00∶7.74∶5.51∶0.5∶0.25∶0.03. Conclusion The Guilong cataplasm prepared under the optimum conditions possess good scalability,smooth appearance,moderate viscosity and moisture. It has good compatibility with Guilong cataplasm powder. |
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| Keywords: | uniform design Guilong cataplasm matrix |
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