| 依帕司他对糖尿病患者心率变异性影响的评价 |
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| 引用本文： | 林令华,许金华,孟凡霞,李志改,于军会,杨华.依帕司他对糖尿病患者心率变异性影响的评价[J].中国医院用药评价与分析,2006,6(5):274-276. |
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| 作者姓名： | 林令华 许金华 孟凡霞 李志改 于军会 杨华 |
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| 作者单位： | 江苏省连云港东海县人民医院,连云港市,222300 |
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| 基金项目： | 江苏省卫生厅临床药学科研项目 |
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| 摘 要： | 目的:评价依帕司他对糖尿病患者心率变异性的影响。方法:收集患者93例,分为治疗组和对照组,治疗组患者接受依帕司他50mg,每日3次治疗,服用4周,运用24小时动态心电图检测所有患者在治疗前后心率变异性指标的变化,明确依帕司他治疗糖尿病心脏自主神经病变的疗效。结果:治疗组心率变异性各项指标治疗4周后较治疗前有显著提高,自主神经症状明显好转,与对照组比较有显著意义。结论:依帕司他治疗糖尿病心脏自主神经病变的疗效显著,可以改善患者心率变异性。
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| 关 键 词： | 依帕司他 糖尿病 心脏自主神经病变 心率变异性 |
| 文章编号： | 1672-2124(2006)05-0274-03 |
| 修稿时间： | 2006年5月23日 |
Evaluation about Effect of Epalrestat on Heart Rate Variability in Patients with Diabetes |
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| LIN Linghua,XU Jinhua,MENG Fanxia,LI Zhigai,YU Junhui,YANG Hua.Evaluation about Effect of Epalrestat on Heart Rate Variability in Patients with Diabetes[J].Evaluation and Analysis of Drug-Use in Hospital of China,2006,6(5):274-276. |
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| Authors: | LIN Linghua XU Jinhua MENG Fanxia LI Zhigai YU Junhui YANG Hua |
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| Abstract: | OBJECTIVE:To evaluate the effect of epalrestat on heart rate variability(HRV) in diabetes.METHODS: A total of 93 patients were assigned to receive 50mg epalrestat t.i.d for four weeks or placebo.The change of the HRV parameters of all patienes was detected using 24-hour DCG(dynamic electrocardiogram),and the efficacy of epalrestat on heart rate variability(HRV) in diabetics with cardiac autonmic neuropathy was investigated.RESULTS: In the treatment group,HRV parameters had a significant improvement four weeks after receiving treatment as against before treatment,cardiac autonmic neuropathy improved significantly,and there were significances as compared with control group.CONCLUSION: Epalrestat is effective for cardiac autonmic neuropathy in patients with diabetes and it can improve patients' HRV. |
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| Keywords: | hpalrestat diabetes cardiac autonmic ncuropathy heart rate variability(HRV) |
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