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Biobehavioral influences on cancer progression |
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| Authors: | Costanzo Erin S Sood Anil K Lutgendorf Susan K |
| Affiliation: | a Department of Psychiatry, Carbone Comprehensive Cancer Center, University of Wisconsin-Madison, 6001 Research Park Boulevard, Madison, WI 53719, USA b Departments of Gynecologic Oncology, Cancer Biology, and Center for RNA Interference and Non-Coding RNA, MD Anderson Cancer Center, University of Texas, Unit 1362, PO Box 301439, Houston, TX 77230, USA c Departments of Psychology, Urology, Obstetrics & Gynecology, Holden Comprehensive Cancer Center, University of Iowa, E11 Seashore Hall, Iowa City, IA 52242, USA |
| Abstract: | This review focuses on the contributions of stress-related behavioral factors to cancer growth and metastasis and the biobehavioral mechanisms underlying these relationships. Behavioral factors that are important in modulation of the stress response and the pivotal role of neuroendocrine regulation in the downstream alteration of physiologic pathways relevant to cancer control, including the cellular immune response, inflammation, and tumor angiogenesis, invasion, and cell signaling pathways are described. Consequences for cancer progression and metastasis, as well as quality of life, are delineated. Behavioral and pharmacologic interventions with the potential to alter these biobehavioral pathways for patients with cancer are discussed. |
| Keywords: | Cancer Stress Depression Immunity Inflammation Angiogenesis |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |