Alterations of lens metabolism with experimentally induced cataract in rats |
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| Authors: | I Korte O Hockwin J Bours A Wegener |
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| Affiliation: | Department of Experimental Ophthalmology, University of Bonn, FRG. |
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| Abstract: | Rat lenses with experimentally induced cataract (either by naphthalene or by streptozotocin) were analyzed biochemically. Both noxae had some effects in common. Water-soluble protein and aldose reductase activity decreased, and glucose-6-phosphate dehydrogenase, phosphofructokinase and glutathione reductase activity increased. A specific effect of streptozotocin was the rise in glucose, fructose and sorbitol. A specific effect of naphthalene was increased amounts of water-insoluble protein. |
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