血清对氧磷酯酶活性变化与糖尿病视网膜病变的关系

目的 探讨对氧磷酯酶(PON)活性变化与2型糖尿病视网膜病变(DR)的关系。方法 用分光光度法检测96例DR患者、82例单纯2型糖尿病(DM)患者及58例正常对照者血清PON的活性；用放免法检测血清免疫反应性胰岛素(IRI)、C肽(C—P)的水平。结果 (1)DR患者血清PON活性明显低于DM患者(F＝11．04，P＜0．01)，DM患者血清PON活性低于正常对照者(F＝16．90，P＜0．01)；(2)PON活性与空腹血清胰岛素及C—P水平无明显相关(r＝0.113，P＞0．05，r＝0．109，P＞0．05)；(3)Logistic回归分析表明，PON活性(P＜0．01)是DR的独立变异危险因素。结论 PON活性变化与DR的发病有关。

The association of paraoxonase (PON) activity with type 2 diabetes mellitus retinopathy

Objective To investigate the association of PON activity with type 2 diabetes mellitus retinopathy (DR). Methods PON activity was estimated by photometer in 82 type 2 diabetes mellitus patients (DM) and 96 DR patients and 58 normal control subjects. Serum immune reactive insulin (IRI) and C peptide (C P) concentration were measured by radio immunity. Results PON activity of DR patients was lower than that of DM patients( F=11.04, P< 0.01) and the activity of DM patients was lower than that of normal control subjects ( F=16.90, P <0.01). Correlation analysis results suggested that there was no significant correlation between PON activity and fasting serum IRI and C P ( r=0.133,P>0.05;r=0.109,P>0.05 ). Logistic regression analysis results suggested that PON activity ( P <0 01) was the independent risk factor of DR. Conclusions PON activity is associated with the pathogenesis of DR.