补肾中药防治绝经后骨质疏松症的实验研究

以股骨矿物质含量和股骨抗弯强度为指标评价补肾中药对骨质疏松症大鼠模型的防治作用。12个月龄雌性SD大鼠行双侧卵巢切除术,术后3个月发现股骨矿物质含量和股骨抗弯强度显著下降(P<0.01),表明骨质疏松模型已形成。然后对模型分别给乙烯雌酚或中药治疗3个月后发现,卵巢切除对照组股骨的矿物质含量和抗弯强度继续下降(P<0.05),而给乙烯雌酚或中药治疗后不再下降而维持在治疗前水平。但两种药物都不能使已经丢失的矿物质和降低的抗弯强度恢复到正常水平。实验结果表明,补肾中药对绝经后骨质疏松大鼠模型有防治作用。

AN EXPERIMENTAL STUDY ON THE PREVENTION AND THERAPY OF POST-MENOPAUSE WITH CHINESE DRUGS

The study evaluated the effects of Chinese drugs on post-menopause osteoporisis rat models by measuring bone mineral contents and bone strengths in femur. Twelve months female S. D rats were ovariectomized. After 3 months, the results demonstrated that ovariectomy reduced the bone mineral contents and bone strength in femur significantly (P<0. 01). It was suggested that the models of post-menopause osteoporosis had alreadly occured. Then, the models were treated with stilbestrol or Chinese drugs for 3 months , it was found that the femur bone mineral contents and bone strength progressively decrease in ovariectomized rats without treatment, in contrast, the femur bone mineral contents and bone strengths didn't decrease in rats treated with stilbostrol or Chinese drugs. But ,the bone mineral contents and bone strength were not reversed to the normal levels. The study demonstrated that the rat models of post-menopause were prevented and treated effectively with Chinese drugs.