生长抑制因子1在子宫内膜异位症的表达

目的:探讨生长抑制因子1(ING1)在子宫内膜异位症(EMs)发病机制中的作用。方法:采用免疫组化SABC法检测40例患者(EMs)在位及异位子宫内膜组织ING1的表达,并与20例正常子宫内膜(对照组)进行比较。结果:ING1在EMs组异位腺体的表达分别低于在位腺体及对照组(P<0.05),在异位间质的表达低于对照组间质(P<0.05);ING1在EMs组、对照组增生期与分泌期的表达及在EMs组I-Ⅱ期与Ⅲ-IV期异位腺体和间质间的表达均无明显差异(P>0.05)。结论:ING1在异位内膜的腺体及间质中的低表达可能在EMs的发病中起重要作用。ING1表达量与EMs的严重程度无关。

Expression of ING1 in Endometriosis

Objective: To investigate the role of inhibitor of growth-1(ING1) in endometriosis. Methods: The expression of the ING1 was detected by immunohistochemical strept avidin biotin complex (SABC) methods in eutopic and ectopic endometrium of the 40 cases endometriosis and compared with 20 control cases. Results: The expression of ING1 in ectopic endometrium glandular was lower than that in eutopic endometrium and the control (P<0.05), in ectopic endomtrium stroma was lower than that in the control (P<0.05). The expression of ING1 had no difference between the profecive and secrecive phase not only in endometriosis but also in the control (P>0.05). The expression of ING1 had no significant difference between the stage Ⅰ -Ⅱ and Ⅲ -Ⅳ of endometriosis (P>0.05). Conclusion: The lower expression of ING1 in ectopic glandular and stroma may play a key role in the pathogenesis of endometriosis. ING1 has no correlation with the severity of endometriosis.