Thrombolysis with low dose tissue plasminogen activator. |
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| Authors: | E Doyle J Britto J Freeman F Munro N S Morton |
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| Affiliation: | Intensive Care Unit, Royal Hospital for Sick Children, Yorkhill, Glasgow. |
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| Abstract: | Two cases of vena caval thrombosis in infants were successfully treated with low dose (0.01-0.05 mg/kg/hour) local infusions of tissue plasminogen activator after conventional anticoagulant treatment had been unsuccessful. This approach is useful for clots associated with indwelling intravascular catheters, and a low dose infusion of tissue plasminogen activator as a regional application is recommended to achieve clot lysis with minimal systemic effects. |
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