脑源性神经营养因子在涎腺腺样囊性癌中的表达及意义

目的]探讨脑源性神经营养因子（BDNF）与涎腺腺样囊性癌（SACC）的关系。方法]采用免疫组织化学方法检测45例SACC切片中BDNF的表达,并统计分析BDNF与SACC组织学分型、临床分期、神经侵犯和远处转移之间的关系。结果]BDNF在SACC中的阳性表达率为84.4%（38/45）,BDNF表达强度与SACC的组织学分型和神经侵犯无明显关系（P〉0.05）,而与临床分期、远处转移关系密切（P〈0.05）。结论]SACC中存在BDNF异常表达,而且BDNF可能促进了SACC的发生发展。

Expression of Brain-derived Neurotrophic Factor in Salivary Adenoid Cystic Carcinoma and its Significance

Purpose] To investigate the relationship between the expression of brain-derived neurotrophic factor（BDNF） and salivary adenoid cystic carcinoma （SACC）. Methods] The expression of BDNF in 45 cases with SACC was detected by immunohistochemistrial method. The relationship between BDNF expression and histological type,clinical staging,perineural invasion and distant metastasis was analyzed. Results] The positive expression of BDNF in SACC was 84.4%（38/45）. The expression level of BDNF wasn’t significantly correlated with histological type and perineural invasion （P〉0.05）,but correlated with clinical staging and distant metastasis （P〈0.05）. Conclusions] BDNF is aberrantly expressed in SACC,and it might promote carcinogenesis and progression of SACC.