Human Regulatory Gene for Inducible Tyrosine Aminotransferase in Rat-Human Hybrids |
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| Authors: | Carlo M. Croce Gerald Litwack Hilary Koprowski |
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| Affiliation: | 1.The Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania 19104;*Fels Research Institute, Department of Biochemistry, Temple University School of Medicine, Philadelphia Pennsylvania 19140 |
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| Abstract: | The inducibility of tyrosine aminotransferase (EC 2.6.1.5) by corticosteroid hormones in rat-human hybrid clones was studied. The presence of human X chromosome activity in the cells was always associated with the suppression of tyrosine aminotransferase inducibility in all the clones examined. Negative correlation between the human X chromosome and inducibility of the enzyme was clearly established. Corticosteroid receptor was present to the same extent in hybrid cell clones that either contained or lost the human X chromosome. The human repressor for inducible tyrosine aminotransferase has a linkage relationship with glucose-6-phosphate dehydrogenase (EC 1.1.1.49) and hypoxanthine-guanine-phosphoribosyltransferase (EC 2.4.2.8) and, therefore, can be assigned to the X chromosome. |
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