升降胶囊对化疗致呕家鸽体内5-羟色胺水平的影响

目的：观察升降胶囊对顺铂所致家鸽呕吐的作用,探讨其防治呕吐的机制。方法：采用家鸽腹腔注射顺铂制造呕吐模型,观察家鸽呕吐频率及呕吐潜伏期;用高效液相色谱-电化学检测法（HPLC-ED）检测家鸽血清、十二指肠组织中5-羟色胺（5-HT）的含量。结果：升降胶囊对化疗致呕家鸽有明确的止呕作用。升降胶囊组家鸽血清和十二指肠组织中5-HT的含量显著减少（P〈0.05）。结论：升降胶囊止呕的机制与降低5-HT水平有关。

The Effect of Sheng-Jiang Capsule on 5-HT in Vomiting Pigeon due to Chemotherapy

Objective:To observe the effect of Sheng-Jiang Capsule on treating cisplatin-induced pigeon's vomiting,and explore the functional mechanism in preventing and treating vomiting.Method:The test was designed to make animal models by injecting the chemical medicine cisplatin in pigeon's abdomen,observing the vomiting times and delitescence,and measuring the levels of 5-hydroxytryptamine(5-HT)in pigeon's blood and duodenum tissue by high performance liquid chromatography with electrochemical detection(HPLC-ED).Result:Sheng-Jiang Capsule can obviously decrease the vomiting times and delay the vomiting delitescence of the pigeons,the 5-HT contents of blood and duodenum tissue in the groups of Sheng-Jiang Capsule are markedly lower than that of model group(P<0.05).Conclusion:Possible mechanism of Sheng-Jiang Capsule is to decrease the level of 5-HT.