| 单核细胞趋化蛋白-1和血管内皮细胞生长因子在人皮肤血管瘤中的表达及其相关性 |
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| 引用本文： | 徐圣康,赵猛,刘家国,张劲松,王玉荣. 单核细胞趋化蛋白-1和血管内皮细胞生长因子在人皮肤血管瘤中的表达及其相关性[J]. 郧阳医学院学报, 2008, 27(3) |
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| 作者姓名： | 徐圣康 赵猛 刘家国 张劲松 王玉荣 |
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| 作者单位： | [1]郧阳医学院附属太和医院创伤骨科,湖北十堰442000 [2]华中科技大学同济医学院附属协和医院整形外科,湖北武汉430022 |
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| 摘 要： | 目的:探讨单核细胞趋化蛋白-1(MCP-1)和血管内皮细胞生长因子(VEGF)在人皮肤血管瘤发生、发展及退化过程中的表达及其相关性。方法:采用免疫组化方法(SP法)和计算机图像分析技术,检测人皮肤血管瘤增生期、消退期及正常皮肤中的MCP-1、VEGF的平均阳性面积率和平均光密度。结果:增生期血管瘤与消退期血管瘤、正常皮肤组分别相比,MCP-1、VEGF阳性表达的平均光密度和平均阳性面积率有显著性差异(P<0.05);消退期血管瘤与正常皮肤组之间,MCP-1、VEGF阳性表达率无显著性差异(P>0.05);MCP-1、VEGF阳性面积表达率呈明显的正相关(r=0.746,P<0.05)。结论:MCP-1、VEGF在人皮肤血管瘤过度增生中起着重要的作用,且二者之间可能具有相互协同作用。
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| 关 键 词： | MCP-1 VEGF 血管瘤 血管生成 免疫组化 |
The Correlation between Monocyte Chemoattractant Protein-1 and Vascular Endothelial Cell Growth Factor Expression in Skin Hemangioma Tissue |
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| XU Sheng-kang,ZHAO Meng,LIU Jia-guo,ZHANG Jin-song,WANG Yu-rong. The Correlation between Monocyte Chemoattractant Protein-1 and Vascular Endothelial Cell Growth Factor Expression in Skin Hemangioma Tissue[J]. Journal of Yunyang Medical College, 2008, 27(3) |
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| Authors: | XU Sheng-kang ZHAO Meng LIU Jia-guo ZHANG Jin-song WANG Yu-rong |
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| Affiliation: | XU Sheng-kang1,ZHAO Meng1,LIU Jia-guo1,ZHANG Jin-song1,WANG Yu-rong2 (1Department of Orthopaedic Trauma,Taihe Hospital,Yunyang Medical College,Shiyan,Hubei 442000,China,2Department of Plastic Surgery,Union Hospital,Tongji Medical College,Huazhong University of Science , Technology,Wuhan,Hubei 430022,China) |
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| Abstract: | Objective To explore the expression of monocyte chemoattractant protein-1(MCP-1) and vascular endothelial cell growth factor(VEGF) in hemangioma and the relationship between MCP-l and VEGF.Method:MCP-l and VEGF expression in 36 cases with hemangioma were detected with immunohistochemistry.The average optical density and the positive area of MCP-1 and VEGF expression in specimens with different stage hemangioma were analyzed with image analysis.Results: Compared regression stage of hemangioma or normal skin ... |
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| Keywords: | Monocyte chemoattractant protein-1 Vascular endothelial cell growth factor Hemangioma Angiogenesis Immunohistochemistry |
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