| 人宫颈癌基因与肿瘤 |
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| 引用本文： | 姚林华,张国新. 人宫颈癌基因与肿瘤[J]. 国际肿瘤学杂志, 2009, 36(12). DOI: 10.3760/cma.j.issn.1673-422X.2009.12.001 |
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| 作者姓名： | 姚林华 张国新 |
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| 作者单位： | 南京医科大学第一附属医院消化科,210029;南京医科大学第一附属医院消化科,210029 |
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| 摘 要： | 人宫颈癌癌基因(HCCR)是在人宫颈癌中发现的新基因,在人类大多数肿瘤中都有表达.研究表明HCCR可作为肝癌、乳腺癌早期诊断的标记物,HCCR表达调节受促分裂原活化蛋白激酶和磷脂酰肌醇3-激酶通路的调节,利用基因干扰技术发现HCCR与肿瘤细胞的增殖、凋亡、浸润及迁移有关.
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| 关 键 词： | 肿瘤 肿瘤标记 生物学 人宫颈癌基因 |
Human cervical cancer oncogene and tumor |
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| YAO Lin-hua,ZHANG Guo-xin. Human cervical cancer oncogene and tumor[J]. Journal of International Oncology, 2009, 36(12). DOI: 10.3760/cma.j.issn.1673-422X.2009.12.001 |
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| Authors: | YAO Lin-hua ZHANG Guo-xin |
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| Abstract: | Human cervical cancer oncogene(HCCR) is newly identified in cervical cancer tissues,and expresses in most human tumors. Resarches show that HCCR is a candidate marker for human hepatocelular carcinoma and breast cancer. Moreover,the expression of HCCR is regulated by mitogen-activated protein kinase (MAPK)and phosphatidylinositol 3-kinase signal pathway. The proliferation,apoptosis,migration and invasion of tumor cells could be inhibited by siRNA of HCCR. |
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| Keywords: | Neoplasms Tumor marker biology Human cervical cancer oncogene |
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