含聚乙二醇两亲性聚合物及其胶束用作药物载体的理论研究及应用潜力

目的:对含聚乙二醇的两亲性聚合物种类、合成及在药物载体领域的应用进行综述.资料来源:应用计算机检索SCI-Expanded、EI Compendex和中国期刊全文数据库2000-01/2009-07关于含聚乙二醇的两亲性共聚物分类、合成及其胶束在药物载体领域研究的相关文献.资料选择:初检得到616篇文献,阅读标题和摘要进行初筛,以含聚乙二醇的两亲性共聚物的分类与合成是否全面细致,对于自主装形成胶束的影响因素是否有相当的代表性及前沿性为纳入标准,共保留31篇中英文文献进行进一步分析.结局评价指标:含聚乙二醇的两亲性共聚物分类、合成、载药机制:共聚物胶束在药物载体领域中的应用情况.结果:①星型共聚物能提高胶束稳定性,但臂数太多,有可能导致载药量降低.②共聚物中引入特定的基团有利于药物与载体的结合;连接靶向基团能使体系提供靶向运送特性.③共聚物中聚乙二醇链的长度和密度与胶束化性能有关,改变聚乙二醇长度和密度可以获得较长时间在体内循环的聚合物胶束.结论:含聚乙二醇的两亲性共聚物在医学载药领域和分离技术方面具有优越的应用潜力.

Theoretical research and application potential of amphiphilic polymers containing polyethylene glycol and their micelles used as drug carriers

OBJECTIVE: To review classification and synthesis of amphiphilic polymers containing polyethylene glycol and the application as drug carriers.DATA SOURCE: A computer-based research was conducted in SCI-Expanded, El Compendex and China Journal Full-text Database for articles concerning classification and synthesis of amphiphilic polymers containing polyethylene glycol and their micelles application as drug carriers published from January 2000 to July 2009.DATA SELECTION: A total of 616 articles were primarily obtained. Following reading titles and abstract, articles addressing detail classification and synthesis of amphiphilic polymers containing polyethylene glycol and representative micellar influencing factor were included. Totally 31 English and Chinese literatures were collected for further analysis.MAIN OUTCOME MEASURES: Classification, synthesis and drug vector mechanism of amphiphilic polymers containing polyethylene glycol and the micellar application as drug carriers were measured.RESULTS: Star-shaped copolymer could elevate micellar stability, but there were many arm numbers, whicti might induced a decrease in drug carrier volume. Special group introduced in copolymer contributed to the combination of drug and carrier. To connect target group could provide target transport property. The length and density of polyethylene glycol chain in copolymer was related to micellar function. Changed the length and density of polyethylene glycol could obtain polymer micelles that circulated in vivo for a long time.CONCLUSION: Amphiphilic polymers containing polyethylene glycol has outstanding potential in medical drug carrier field and isolation technique.