| eIF-4E、p53在皮肤鳞状细胞癌中的表达及其临床意义 |
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| 作者单位： | Department of Dermatology, TongJi Hospital, TongJi Medical College, Huazhong University of Science and Technology, Wuhan 430030
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| 摘 要： |
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| 关 键 词： | 翻译起始因子4E 真核细胞起始因子 鳞状细胞癌 临床意义 p53 正常皮肤组织 SABC 免疫组化 |
The expression and the clinical significance of eukaryotic translation initiation factors 4E and p53 in squamous cell carcinoma |
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| Authors: | Shenqiu Li Qinjing Wei |
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| Institution: | Department of Dermatology, TongJi Hospital, TongJi Medical College, Huazhong University of Science and Technology, Wuhan 430030 |
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| Abstract: | Objective:To study the expression of eukaryotic initiation factor-4E (eIF-4E) and p53 in squamous cell carcino-mas (SCC) and to explore their relationship and clinical significance. Methods:The expression of eIF-4E and p53 in 32 cases of SCC was detected by immunohistochemical SABC method. Results:The positive rate of eIF-4E and p53 expression was 93.8% and 56.3% in SCC, and the levels of eIF-4E and p53 were significantly higher in SCC than those in the normal skin tissue (P < 0.05). Conclusion:Both eIF-4E and p53 were useful markers in SCC, but the specialty and sensitivity of the eIF-4E protein was high in SCC. |
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| Keywords: | squamous cell carcinoma (SCC) eukaryotic initiation factor-4E (eIF-4E) p53 |
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