| 透明质酸对体外伤口收缩模型的影响 |
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| 引用本文： | 郭爱华,柳大烈. 透明质酸对体外伤口收缩模型的影响[J]. 中国组织工程研究与临床康复, 2002, 6(18): 2693-2694 |
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| 作者姓名： | 郭爱华 柳大烈 |
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| 作者单位： | 解放军沈阳军区总医院,辽宁沈阳,110015 |
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| 摘 要： | 目的研究影响伤口收缩的因素,使其能有利于伤口愈合,又不致引起瘢痕的异常增生。方法建立以瘢痕成纤维细胞和I型胶原混悬液形成的胶原网架凝胶块,来模拟体内伤口收缩,观察透明质酸(HA)对其收缩的影响。结果发现HA在一定浓度范围内对伤口收缩有剂量依赖型抑制作用。结论HA有抑制瘢痕形成和异常收缩作用,为临床应用提供指导意义。
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| 关 键 词： | 透明质酸 瘢痕 成纤维细胞 伤口收缩 胶原网架 |
| 文章编号： | 1671-5926(2002)18-2693-02 |
| 修稿时间： | 2002-06-26 |
Effect of hya luronic acid on in vitro model of wound contraction |
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| GUO Ai-hua,LIU Da-lie.Sh enyang Gen eral Hospital of PLA,Shenyang,China. Effect of hya luronic acid on in vitro model of wound contraction[J]. Journal of Clinical Rehabilitative Tissue Engineering Research, 2002, 6(18): 2693-2694 |
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| Authors: | GUO Ai-hua LIU Da-lie.Sh enyang Gen eral Hospital of PLA Shenyang China |
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| Affiliation: | GUO Ai-hua,LIU Da-lie.Sh enyang Gen eral Hospital of PLA,Shenyang110015,China |
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| Abstract: | Objecti ve To investigate the factors which effect the wound contraction.Methods We buil t fibroblast populated colla gen lattice(FPCL)whichwas a collagengelsimilar to granular structure that was formedby t he mixture ofcultured fibroblasts f romh ypertrophic scar andsoluble collagen type I.FPCL contraction is similar to woun d contraction.The effect of HAon invitro model of wound co ntration was examine d.Results The does-dependent inhibition of lattice contration caucing by HAwit hin a c ertain limit.Conclusions Incorporate with the anterior findi ng that H Ain-hibited the proliferation and colla gen synthesization by fibroblast su gge st that HA may play a major role in r educing scar formation and over-contratio n.This might be useful in clinical practive of promoting wound healing and prev enting extra s car formation. |
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| Keywords: | hyaluronic acid scar wound contra cti on FPCL |
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