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Facilitated diffusion of carbon dioxide in whole blood and hemoglobin solutions |
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| Authors: | Kazuo Tanishita Ichiro Tanasawa Takami Yamaguchi Motoaki Sugawara |
| Affiliation: | (1) Department of Mechanical Engineering, Faculty of Science and Technology, Keio University, Hiyoshi, Kohoku-ku, 223 Yokohama, Japan;(2) Institute of Industrial Science, University of Tokyo, Minato-ku, 106 Tokyo, Japan;(3) Department of Surgical Science, Heart Institute of Japan, Tokyo Women's Medical College, Shinjuku-ku, 162 Tokyo, Japan;(4) Present address: Department of Vascular Physiology, National Cardiovascular Center Research Institute, 565 Suita, Osaka, Japan |
| Abstract: | The values of effective permeability (Krogh's diffusion coefficient) for carbon dioxide have been measured in horizontal stationary layers of whole blood and hemoglobin solutions in quasi-steady state, with the goal of understanding the specific nature of facilitated diffusion of carbon dioxide occurring in these media. The average partial pressure of carbon dioxide within the layer ranged from 0.74 kPa (5.6 mm Hg) to 15.7 kPa (118 mm Hg). Facilitation effects were significant in hemolysed blood and in hemoglobin solutions at low pCO2; the facilitation factor was up to 2.3. Facilitation effects were considerably less for intact blood; the facilitation factor of intact blood with hematocrit 45% was 0.3. The presence of the red cell membrane appears to have a negative effect on facilitation of carbon dioxide transport. |
| Keywords: | Carbon dioxide Permeability Facilitated diffusion Blood Hemoglobin solutions |
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