| 中国汉族、日本、欧裔和非裔人群SNP始祖多态位点的鉴定 |
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| 引用本文： | 赵美乐,齐守文,刘良,曾昭书,王菡,黄艳梅,吴少军,黄代新. 中国汉族、日本、欧裔和非裔人群SNP始祖多态位点的鉴定[J]. 郑州大学学报(医学版), 2007, 42(3): 540-542 |
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| 作者姓名： | 赵美乐 齐守文 刘良 曾昭书 王菡 黄艳梅 吴少军 黄代新 |
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| 作者单位： | 华中科技大学同济医学院法医学系,武汉,430030;河南省高级人民法院,郑州,450008;河南省高级人民法院,郑州,450008;华中科技大学同济医学院法医学系,武汉,430030;郑州大学基础医学院法医学教研室,郑州,450001;新乡医学院法医物证学教研室,新乡,453003 |
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| 摘 要： | 目的:应用全基因组单核苷酸多态性(SNP)基因分型数据及始祖多态位点(AIMs)推断区分人亚群.方法:从国际公共数据库中选取中国汉族、日本人、欧裔和非裔4个人群270个样本4 396 943个SNP位点的基因分型结果.用Perl语言编写数据提取程序,从中得到1 136个群体间等位基因频率差值大于0.3的SNP位点.根据每一个位点在不同人群之间多态性的差异,最终鉴定出44个始祖多态位点.结果:这44个位点联合应用,可以区分其归属于欧裔、非裔、中国汉族或日本人群,并可高度可信地区分中国汉族和日本人群.结论:这一套始祖构成位点的鉴定和应用,为中国人群的疾病关联分析研究、个体医疗、群体遗传学和法庭科学研究等相关科学提供了帮助.
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| 关 键 词： | 法医学 单核苷酸多态性 基因分型 始祖多态位点 种族 |
| 收稿时间： | 2007-01-17 |
| 修稿时间： | 2007-01-17 |
Discrimination of SNP ancestry informative markers for Japanese, European, African and Chinese Han populations |
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| ZHAO Meile,QI Shouwen,LIU Liang,ZENG Zhaoshu,WANG Han,HUANG Yanmei,WU Shaojun,HUANG Daixin. Discrimination of SNP ancestry informative markers for Japanese, European, African and Chinese Han populations[J]. Journal of Zhengzhou University: Med Sci, 2007, 42(3): 540-542 |
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| Authors: | ZHAO Meile QI Shouwen LIU Liang ZENG Zhaoshu WANG Han HUANG Yanmei WU Shaojun HUANG Daixin |
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| Affiliation: | 1 Department of Forensic Medicine, Tongji Medical College, Huangzhong University of Science and Technology , Wuhan 430030 ;2 Henan High Court, Zhengzhou 450008 ;3 Department of Forensic Medicine, College of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001 ;4 Department of Forensic Biological Evidence, Xinxiang Medical College, Xinxiang 453003 |
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| Abstract: | Aim: To distinguish different populations from the whole genome SNP genotyping data with the ancestry informative markers(AIMs)inference method.Methods:From international public databases, we retrieved 4 396 943 genotypes of (SNPs) from 270 samples including 4 populations: Japanese, European, African and Chinese Han populations. Using Perl language to extract data,1 136 SNPs were picked out with allele frequency difference between each group larger than 0.3. Finally 44 loci were identified to be AIMs.Results: Using the genotypes of these 44 AIMs, we could infer a person is a European, or an African, or a Han Chinese, or a Japanese or not. Especially, Han Chinese and Japanese can be distinguished with high credit. Conclusion: The identification and application of these 44 AIMs is helpful in the disease association analysis, individualized health care,population genetics, forensics and other related sciences for Chinese population. |
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| Keywords: | forensic medicine single nucleotide polymorphism genotyping ancestry informative marker population |
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