硼酸对去卵巢大鼠雌激素样作用的观察

目的:评价硼酸的体内雌激素样效应.方法:40只SD大鼠行双侧去卵巢后,随机分为5组,阴性对照组(蒸馏水),低、中、高剂量硼酸组(4 mg/kg、25 mg/kg及75 mg/kg)及阳性对照组(0.10 mg/kg 雌二醇),连续给药3 d后处死大鼠,测定子宫脏器系数及血清总雌二醇水平.结果:阳性对照组子宫脏器系数及血清雌二醇水平均高于阴性对照组(P均＜0.05).高剂量硼酸组大鼠子宫脏器系数高于阴性对照组(P＜0.05);硼酸各剂量组血清雌二醇水平与阴性对照组相比,差异均无统计学意义(P均＞0.05).结论:硼酸能够诱导去卵巢大鼠子宫增重,具有雌激素样效应.

Observation on estrogenic effects of boric acid in ovariectomized rats

Aim: To evaluate the potential estrogenic effect of boric acid in vivo.Methods:A total of 40 rats without ovary were randomly divided into 5 groups: negative control group (distilled water), low-,mid-,and high-dose boric acid groups (4 mg/kg, 25 mg/kg, and 75 mg/kg boric acid), and positive control group (0.10 mg/kg estradiol). Boric acid was administered by gavage for 3 days. The weight of uterus of ovariectomized SD rats and concentration of estradiol in blood serum were measured. Results: The uterine organ coefficient and concentration of estradiol in blood serum were higher than those of positive control group (P<0.05). Uterine organ coefficient significantly increased in the high-dose group, compared with control (P<0.05). Concentration of estradiol in blood serum had no statistically difference in groups of boric acid, compared with control (P>0.05).Conclusion: Boric acid could stimulate the growth of uterus of ovariectomized rats and has estrogenic effect.