中心动脉压、血尿酸浓度与冠心病的相关性

目的探讨中心动脉压、血尿酸与冠心病的相关性。方法随机选择我院2006年7月至2008年6月96例冠状动脉造影确诊为冠心病患者,冠状动脉造影结束后,同步测量升主动脉根部(直接测量法)和肱动脉(袖带加压法)的血压,其中合并高血压组53例,非高血压组43例;采用酶法测定血尿酸浓度。结果冠心病合并高血压组血尿酸浓度(380±87)μmoL/L]高于非高血压组(332±90)μmol/L,P0.05],其他因素差异无统计学意义(P0.05)。相关分析显示,血尿酸浓度与中心动脉收缩压(CSP)及脉压显著呈正相关(r=0.411、0.364,P0.01);与中心动脉舒张压(CDP)及肱动脉收缩压(BSP)亦呈正相关(r=0.273、0.256,P0.05)。冠状动脉病变程度与高尿酸血症发生率呈正相关(21.3%比49.0%,P0.01)。Logistic回归分析显示年龄、中心动脉脉压、血尿酸浓度(OR=1.091、1.059、1.010,P0.05)是冠状动脉病变程度的危险因素。结论中心动脉压、血尿酸升高与冠心病的发生率及病变程度关系密切,中心动脉压较肱动脉压与血尿酸水平具有更显著的相关性。

Relationship among central aortic pressure,serum uric acid and coronary heart disease

Objective To explore the relationship among the level of serum uric acid, central aortic pressure and coronary heart disease （CHD）. Methods This study included 96 in-hospital patients who were selected randomly from July 2006 to June 2008 . All the patients were diagnosed as CHD by clinical findings and coronary angiography. Ascending aortic pressure with catheters and brachial blood pressure with a standard sphygmomanometer were measured simutaneously at the end of coronary angiography procedure. All cases were divided into hypertension group （n = 53）and non-hypertension group （n = 43）. The serum uric acid （UA） was detected with auto analyzer using enzyme method. Results Serum uric acid levels were higher in hypertension group （380 ±87） umol/L] than in non-hypertension group （332 ±90） umol/ L,P 〈 0. 05 ]. There were significant correlation between UA with central systolic pressure （CSP） and central aortic pulse pressure （r =0. 411, 0. 364,both P 〈0. 01 ） ,and a positive correlation between UA with central diastolic pressure （CDP） and brachial systolic pressure （BSP） （r = 0. 273,0. 256, both P 〈 0. 05）. There was a higher incidence of high UA in multi-vessel disease than in single-vessel disease （21.3% vs. 49.0% ,P 〈 0. 01 ）. Logistic regression analysis revealed that age,central aortic PP and UA were risk factors of CHD （ OR = 1. 091, 1. 059 and 1. 010, all P 〈 0.05）. Conclusions The increases of central aortic pressure and UA are related to the severity of CHD. There is more significant correlation between central aortic pressure and serum UA than brachial blood pressure.