基因多态性与非霍奇金淋巴瘤易感性关系的流行病学研究

非霍奇金淋巴瘤(NHL)发病呈上升趋势,但病因不十分清楚。基因多态性被认为是引起疾病如肿瘤易感的重要因素。本文从流行病学的角度综述了国内外有关基因多态性与NHL关系的研究结果。虽然有一些研究发现基因多态性可以增加NHL发病的危险性,但还需要更多的流行病学研究。文章最后对今后的研究重点提出了建议。

Epidemiology studies on associations between gene polymorphisms and non-Hodgkin''''s lymphoma

The incidence of non-Hodgkin's lymphoma(NHL) has been increasing in last twenty years. However, the etiology of NHL is not unclear. Gene polymorphisms were demonstrated to play important roles in human susceptibility to diseases such as cancers. This paper reviews epidemiology studies of associations between polymorphisms in genes involved in immunity regulation, chemical and folate metabolism, DNA repair, cell cycle and oncogenes and NHL. Although some positive associations between gene polymorphisms and NHL incidence risk were observed, more epidemiology studies are necessary. In future studies, haplotype tagging SNPs and gene-environmenal interactions should be identified.