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Review article: gastro-oesophageal reflux disease and psychological comorbidity |
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| Authors: | I. MIZYED,S. S. FASS,& R. FASS |
| Affiliation: | The Neuroenteric Clinical Research Group, Section of Gastroenterology, Department of Medicine, Southern Arizona VA Health Care System and University of Arizona Health Sciences Center, Tucson, AZ, USA |
| Abstract: | Background A growing number of studies have shown the impact of psychological comorbidities on gastro-oesophageal reflux disease (GERD) patients' symptom reports and healthcare-seeking behaviour. Aim To review the reported relationship between GERD and psychological comorbidity. Methods Review of the literature on GERD and psychological comorbidity. Results Psychological comorbidity is common among GERD patients and appears to afflict all GERD phenotypes. Sexual and physical abuse is also common in GERD patients. Stress enhances perception of oesophageal acid exposure. Treatment for GERD, especially in those who are not responsive to antireflux treatment, may require further evaluation for psychological comorbidity. Conclusions Psychological comorbidity is very common in GERD patients and is likely to play an important role in response, or failure of response, to proton pump inhibitor treatment. |
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