包皮表皮细胞中肌动蛋白表达规律研究

目的 探讨不同年龄段包皮组织中a-Actin的表达规律。方法 用免疫组化染色法对98例3～25岁男性包皮组织中Actin的表达情况进行研究。结果 15岁前男子包皮表皮细胞中a-Actin的表达水平较高并保持恒定，包茎和单纯包皮过长的小Actin表达差异无显著意义15岁后单纯包皮过长的表皮细胞中的a-Actin表达明显下降，也较同年龄组的包茎明显降低。结论 性成熟前男子中包皮表皮细胞中a-Actin的表达水平较高，可能是一种参与男子外生殖器发育成熟的重要因素。

Study on a-Actin expression in epidermal cells of prepuce

Objectiv To investigate the expression of a-Actin in epidermal cells of prepuce at different age groups.immunohistochemical stain metbods.Results A stable high level of a-Actin expression in epidermal cells was revealed during puberty and the diference in a-Actin expression between phimosis and abundant prepuce was not significant.After the age of 15 years.the a-Actin expresssion in abundant prepuce significantly decrcased.and also showed a low level compared with the phimosis at the matched age group.Conclusions A relatively high levels of a-Actin expression in epidermal cells of prepuee is revealed before sexual maturation,which may play an important role in genital differentiation.