| 高频振动对尾部悬吊大鼠比目鱼肌梭内、外肌纤维肌球蛋白重链表达的影响 |
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| 引用本文： | 杨威,樊小力,吴苏娣,宋新爱.高频振动对尾部悬吊大鼠比目鱼肌梭内、外肌纤维肌球蛋白重链表达的影响[J].航天医学与医学工程,2004,17(3):166-170. |
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| 作者姓名： | 杨威 樊小力 吴苏娣 宋新爱 |
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| 作者单位： | 西安交通大学医学院生理学教研室,陕西西安,710061;西安交通大学医学院生理学教研室,陕西西安,710061;西安交通大学医学院生理学教研室,陕西西安,710061;西安交通大学医学院生理学教研室,陕西西安,710061 |
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| 基金项目： | 国家自然科学基金资助 ( 3 0 0 70 83 0 ) |
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| 摘 要： | 目的 观察高频正统波振动对尾部悬吊大鼠比目鱼肌（SOL）梭内、外肌纤维MHC表达的影响。方法 采用大鼠尾部悬吊法建立模拟失重模型，高频正弦波振动大鼠比目鱼肌。用免疫组织化学技术，观察大鼠比目鱼肌（SOL）梭内、外肌纤维MHC表达变化。结果 尾部悬吊7d后大鼠比目鱼肌梭内、外肌纤维中快缩型MHC的表达均有所增加，而在另尾期间给予高频正弦波振动比目鱼肌后梭内、外肌快缩型MHC表达没有明显变化。结论 高频正弦波振动尾部悬吊大鼠比目鱼肌梭内、外肌纤维MHC表型转化有明显的对抗作用。
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| 关 键 词： | 失重模拟 尾部悬吊 高频振动 肌梭 基因表达 梭内肌纤维 梭外肌纤维 比目鱼肌 |
| 文章编号： | 1002-0837(2004)03-0166-05 |
Effects of High Frequency Vibration on Expression of Myosin Heavy Chain(MHC) in Intrafusal and Extrafusal Fibers in Soleus Muscles of Tail-suspended Rats |
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| YANG Wei,FAN Xiao-li,WU Su-di,SONG Xin-ai.Space Medicine & Medical Engineering.Effects of High Frequency Vibration on Expression of Myosin Heavy Chain(MHC) in Intrafusal and Extrafusal Fibers in Soleus Muscles of Tail-suspended Rats[J].Space Medicine & Medical Engineering,2004,17(3):166-170. |
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| Authors: | YANG Wei FAN Xiao-li WU Su-di SONG Xin-aiSpace Medicine & Medical Engineering |
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| Affiliation: | Department of Physiology, Xi'an Jiaotong University, Shanxi Xi'an, China. |
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| Abstract: | Objective To study the effects of high frequency vibration on expression of myosin heavy chain(MHC) in intrafusal and extrafusal fibers in soleus muscles of tail-suspended rats. Method Weightlessness was simulated by tail suspension of female rats.Using immunohistochemistry technique,changes of expression of MHC in intrafusal and extrafusal fibers of soleus muscles were detected. Result Expression of fast MHC in intrafusal and extrafusal fibers of soleus muscles increased during 7 d of simulated weightlessness,whereas during 7 d of tail suspenion plus high frequency vibration,these changes were not detected.Conclusion High frequency vibration can counteract the changes in expression of MHC in intrafusal and extrafusal fibers of rats soleus under muscles of rats in simulated weightlessness situation. |
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| Keywords: | weightlessness simulation tail suspension high frequency vibration muscle spindle gene expression intrafusal fibers extrafusal fibers soleus |
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