Activation and inactivation of 3-hydroxy-3-methylglutaryl coenzyme a reductase in aged rat liver |
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| Authors: | Nozomu Takeuchi Hitoshi Kukita Yoshiaki Katayama Masafumi Koga Kiyohisa Uchida |
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| Affiliation: | 1. The Central Laboratory, Ehime University Hospital, Shigenobu-cho, Ehimek-en 791-02, Japan;2. The Third Department of Internal Medicine, Osaka University Hospital, Fukushima-ku, Osaka 553, Japan |
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| Abstract: | Activation and inactivation of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase, which is a key enzyme of cholesterol synthesis, were examined in young and aged rats in vitro.The reductase activity in the liver microsomes of aged rats was always lower than that of young rats at various experimental conditions in vitro. But activation and inactivation of the reductase could operate on liver microsomes in aged rats as well as in young rats. Function of hepatic cytosol activator in aged rats seemed to be identical to that in young rats. |
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