|
|||||
|
|
The characteristics and pivotal roles of triggering receptor expressed on myeloid cells-1 in autoimmune diseases |
|
| Authors: | Sheng Gao Yongdong Yi Guojun Xia Chengyang Yu Chenmin Ye Fuyang Tu Leibin Shen Wenqian Wang Chunyan Hua |
| Affiliation: | 1. Laboratory Animal Center, Wenzhou Medical University, Wenzhou 325035, Zhejiang Province, China;2. Department of Gastrointestinal Surgery, The Second Affiliated Hospital and Yuying Children''s Hospital of Wenzhou Medical University, Wenzhou 325027, Zhejiang Province, China;3. Department of Breast Surgery, The Second Affiliated Hospital and Yuying Children''s Hospital of Wenzhou Medical University, Wenzhou 325027, Zhejiang Province, China;4. School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou 325035, Zhejiang Province, China |
| Abstract: | Triggering receptor expressed on myeloid cells-1 (TREM-1) engagement can directly trigger inflammation or amplify an inflammatory response by synergizing with TLRs or NLRs. Autoimmune diseases are a family of chronic systemic inflammatory disorders. The pivotal role of TREM-1 in inflammation makes it important to explore its immunological effects in autoimmune diseases. In this review, we summarize the structural and functional characteristics of TREM-1. Particularly, we discuss recent findings on TREM-1 pathway regulation in various autoimmune diseases, including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), inflammatory bowel disease (IBD), type 1 diabetes (T1D), and psoriasis. This receptor may potentially be manipulated to alter the inflammatory response to chronic inflammation and possible therapies are explored in this review. |
| Keywords: | TREM-1 triggering receptor expressed on myeloid cells-1 RA rheumatoid arthritis SLE systemic lupus erythematosus IBD inflammatory bowel disease T1D type 1 diabetes TLRs toll like receptors NOD nucleotide-binding oligomerization domain NLRs NOD-like receptors DAP12 DNAX-activation protein 12 DCs dendritic cells ECs endothelial cells HMGB1 high-mobility group box 1 HSP70 heat shock protein 70-kDA PGLYRP1 peptidoglycan recognition receptor 1 SSc systemic sclerosis RAGE receptor for advanced glycation end-products IIM idiopathic inflammatory myopathy PGRPs peptidoglycan recognition proteins CKD chronic kidney disease ZAP70 zeta-chain-associated protein kinase 70 SYK spleen tyrosine kinase Cbl casitas b-lineage lymphoma SOS son of sevenless GRB2 growth factor receptor binding protein-2 PI3K phosphatidylinositol 3-kinase PLC-γ phospholipase-C-γ Elk1 ETS domain-containing protein NFAT nuclear factor of activated T-cells PRRs pattern recognition receptors PAMPs pathogen-associated molecular patterns CIA collageninduced arthritis JIA juvenile idiopatic arthritis BAFF B cell-activating factor CD crohn's disease UC ulcerative colitis MPO myeloperoxidase HLA human leukocyte antigen HIF-1α hypoxia inducible factor-1α TREM-1 Inflammation Autoimmune disease Therapy |
| 本文献已被 ScienceDirect 等数据库收录！ | |