滋肾生血方对肾性贫血长期血液透析患者内源性促红细胞生成素的影响

目的通过观察滋肾生血方对长期血液透析患者内源性促红细胞生成素的影响,探讨其治疗肾性贫血的作用机制。方法60例肾性贫血的长期血液透析患者随机分为治疗组30例与对照组30例,分别采用滋肾生血方口服配合重组人类促红细胞生成素(rHuEpo)皮下注射和仅皮下注射rHuEpo治疗,疗程8周,比较两组患者的内源性人红细胞生成素(Epo)、血红蛋白(Hgb)、红细胞压积(Hct)、残余肾功能(RRF)等。结果对照组血清Epo水平较用药前无明显改善(P0.05),治疗组血清Epo水平较用药前明显升高,与对照组比较,差异有统计学意义(P0.05)。两组Hgb、Hct均较用药前明显上升(P0.01),且治疗组高于对照组,差异有统计学意义(P0.01)。两组RRF较用药前均有所下降,且对照组RRF较治疗组下降明显,差异有统计学意义(P0.05)。结论滋肾生血方能提高血清Epo、Hgb及Hct水平,延缓长期血液透析患者的残余肾功能的下降,改善患者的肾性贫血状态。其机制可能是在促进内源性Epo分泌的同时,减轻尿毒症毒素对红细胞生成的抑制作用。

Effect of Zishen Shengxue Recipe on Endogenous Erythropoietin in Patients with Renal Anemia Undergoing Long-term Hemodialysis

Objective To investigate the mechanism of Zishen Shengxue Recipe(ZSR) in treating renal anemia by observing its effect on serum level of endogenous erythropoietin in patients undergoing long-term hemodialysis. Methods Sixty renal anemia patients undergoing long-term hemodialysis were randomly and equally assigned to two groups.The treated group was treated with subcutaneous injection of erythropoiesis stimulating factor(rHuEpo) combined with oral intake of ZSR,and the control group treated with rHuEpo alone...