SNP rs2071095 in LincRNA H19 is associated with breast cancer risk |
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| Authors: | Ping Cui Yanrui Zhao Xinlei Chu Na He Hong Zheng Jiali Han Fengju Song Kexin Chen |
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| Affiliation: | 1.Department of Epidemiology and Biostatistics, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy in Ministry of Education,Tianjin Medical University Cancer Institute and Hospital,Tianjin,People’s Republic of China;2.Department of Cancer Biobank, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Tianjin’s Clinical Research Center for Cancer, National Clinical Research Centre of Cancer,Tianjin Medical University Cancer Institute and Hospital,Tianjin,People’s Republic of China;3.Department of Epidemiology, Fairbanks School of Public Health, Indiana University Melvin and Bren Simon Cancer Center,Indiana University,Indianapolis,USA |
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| Abstract: | PurposeAn increasing number of long intergenic non-coding RNAs (lincRNAs) appear to play critical roles in cancer development and progression. To assess the association between SNPs that reside in regions of lincRNAs and breast cancer risk, we performed a large case-control study in China.MethodsWe carried out a two-stage case-control study including 2881 breast cancer cases and 3220 controls. In stage I, we genotyped 17 independent ( r2? ResultsWe identified 2 SNPs significantly associated with breast cancer risk in stage I (P?P?=?0.002), but not in ER-negative ones (P?=?0.332). Expression levels of H19 in breast cancer cases with AA genotype were significantly lower than those with CC genotype.ConclusionsWe identified that rs2071095 may contribute to the susceptibility of breast cancer in Chinese women via affecting H19 expression. The mechanisms underlying the association remain to be investigated. |
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