| 人参皂甙Rd对高原大鼠运动疲劳后学习记忆及海马CA1区超微结构的影响 |
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| 引用本文： | 曲传勇,杨金升,石向群,司江华,张明磊,范磊,王彦平.人参皂甙Rd对高原大鼠运动疲劳后学习记忆及海马CA1区超微结构的影响[J].国外医学：物理医学与康复学分册,2010,5(2):79-82,138. |
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| 作者姓名： | 曲传勇 杨金升 石向群 司江华 张明磊 范磊 王彦平 |
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| 作者单位： | 兰州军区兰州总医院神经内科; |
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| 基金项目： | 全军“十一五”科技攻关项目(08G010) |
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| 摘 要： | 目的:观察人参皂甙Rd对高原运动疲劳后大鼠学习记忆能力及海马CA1区超微结构改变的影响。方法:健康成年Wistar大鼠24只,由兰州用汽车直接引入青海省可可西里高原,随机分为对照(A)组、生理盐水重度疲劳(B)组及人参皂甙重度疲劳(C)组各8只;A组正常饲养,不运动;采用跑台运动方式建立重度疲劳模型,B、C组分别腹腔给予生理盐水(2mg/kg)或人参皂甙Rd(2mg/kg);Morris水迷宫测试大鼠学习记忆能力,HE染色观察大鼠海马组织形态学改变,透射电子显微镜观察海马CA1区神经元超微结构的改变。结果:与A组相比,B组大鼠逃避潜伏期显著延长(P0.01),海马CA1区超微结构发生病理性改变,C组大鼠逃避潜伏期较B组缩短(P0.05),海马CA1区超微结构病理性改变减轻。结论:人参皂甙Rd可缓解高原环境重度疲劳导致的大鼠学习记忆能力减退及海马神经元损伤。
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| 关 键 词： | 人参皂甙Rd 高原 运动疲劳 学习记忆 海马超微结构 |
Effects of Ginsenoside Rd on Cognition and the Ultrastrueture in CA1 Region of the Hippocampus in Rats after Exercise-induced Fatigue in Plateau Environment |
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| QU Chuan-yong,YANG Jin-sheng,SHI Xiang-qun,SI Jiang-hua,ZHANG Ming-lei,FAN Lei,WANG Yan-ping.Effects of Ginsenoside Rd on Cognition and the Ultrastrueture in CA1 Region of the Hippocampus in Rats after Exercise-induced Fatigue in Plateau Environment[J].Neural Injury and Functional Reconstruction,2010,5(2):79-82,138. |
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| Authors: | QU Chuan-yong YANG Jin-sheng SHI Xiang-qun SI Jiang-hua ZHANG Ming-lei FAN Lei WANG Yan-ping |
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| Institution: | QU Chuan-yong,YANG Jin-sheng,SHI Xiang-qun,SI Jiang-hua,ZHANG Ming-lei,FAN Lei,WANG Yan-ping. Department of Neurology,General Hospital of Lanzhou PLA,Lanzhou 730050,China |
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| Abstract: | Objective:To investigate the effect of ginsenoside Rd on the cognition and ultrastructural changes in hippocampal CA1 region of rat after exercise-induced fatigue in plateau. Methods:Twenty-four healthy adult Wistar rats were randomly divided into three groups:saline control group,severe fatigue group with saline treatment,and severe fatigue group treated with ginsenoside Rd. Rats were taken from Lanzhou to kekexili plateau(4767 m). Rats in saline control group were raised commonly without exercise. Treadmi... |
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| Keywords: | ginsenoside Rd plateau exercise-induced fatigue cognition hippocampus ultrastructure |
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