注射用盐酸表柔比星与胰岛素在葡萄糖注射液中的配伍稳定性考察

目的:考察在葡萄糖溶液中表柔比星和胰岛素配伍的稳定性。方法:观察室温、避光24 h内表柔比星-胰岛素-5%葡萄糖配伍液的外观、pH、不溶性微粒的变化,采用高效液相色谱法考察配伍液中表柔比星、胰岛素含量的变化。结果:配伍液在24 h内无浑浊、沉淀、气体产生,颜色、pH、不溶性微粒数等无明显变化,表柔比星、胰岛素含量无明显变化。结论:在室温下避光放置24 h,表柔比星、胰岛素在5%的葡萄糖注射液中配伍稳定。

Compatible Stability of Insulin Injections Mixed with Epirubicin Hydrochloride for Injection in Glucose Infusions

Objective： To observe the compatibility of insulin and epirubicin for injection in 5% glucose infusions（GS）.Method： The changes in appearance,particles and pH of the mixture in 24h at ambient temperature and light-avoiding condition were observed.The concentrations of insulin and epirubicin were determined by HPLC.Result： No obvious changes in appearance,color,gas,precipitation,turbidity or the number of insoluble particles were shown.The contents of insulin and epirubicin in 24h were kept stable.Conclusion： Insulin injections mixed with epirubicin for injection in 5% GS is stable in 24h under the testing conditions.