| 抗结核治疗中保肝药的预防性应用分析 |
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| 引用本文： | 董亚君,张秋红,乔东,郭振勇.抗结核治疗中保肝药的预防性应用分析[J].中国药师,2012,15(9):1308-1309. |
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| 作者姓名： | 董亚君 张秋红 乔东 郭振勇 |
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| 作者单位： | 北京市结核病胸部肿瘤研究所/首都医科大学附属北京胸科医院药剂科,北京,101149 |
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| 摘 要： | 目的:了解在抗结核治疗过程中保肝药对药物性肝损害的预防作用。方法:对比分析4 927例初始抗结核治疗加用保肝药与未用保肝药患者治疗6个月内转氨酶变化情况,分析保肝药对肝损害的预防性作用。结果:2 771例未使用保肝药者中有2 193例(79.14%)在治疗6个月内出现转氨酶异常,而2 156例使用保肝药者中有984例(45.64%)在治疗6个月内出现转氨酶异常,差异有统计学意义(P<0.01)结论:初始治疗即加用保肝药可以有效减少患者肝损害的发生。
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| 关 键 词： | 结核 药物疗法 保肝药 预防性应用 |
| 收稿时间： | 2012/3/23 0:00:00 |
| 修稿时间： | 2012/5/18 0:00:00 |
Prophylactic Application of Hepatoprotectants in Anti TB Treatment |
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| Dong Yajun,Zhang Qiuhong,Qiao Dong,Guo Zhenyong,Dong Yajun,Zhang Qiuhong,Qiao Dong,Guo Zhenyong,Dong Yajun,Zhang Qiuhong,Qiao Dong,Guo Zhenyong and Dong Yajun,Zhang Qiuhong,Qiao Dong,Guo Zhenyong.Prophylactic Application of Hepatoprotectants in Anti TB Treatment[J].China Pharmacist,2012,15(9):1308-1309. |
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| Authors: | Dong Yajun Zhang Qiuhong Qiao Dong Guo Zhenyong Dong Yajun Zhang Qiuhong Qiao Dong Guo Zhenyong Dong Yajun Zhang Qiuhong Qiao Dong Guo Zhenyong and Dong Yajun Zhang Qiuhong Qiao Dong Guo Zhenyong |
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| Institution: | (Beijing Chest Hospital Affiliated to Peking Capital University,Beijing 101149,China) |
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| Abstract: | Objective： To understand the prophylactic effect of hepatoprotectants in the anti-TB treatment.Method： Totally 4 927 cases with or without hepatoprotectant treatment were compared and the change in transaminase was analyzed.Result： Totally 2 193 in 2 771 cases（79.14%） without hepatoprotectant treatment had hepatic abnormality in 6 months of the initial treatment,while only 984 in 2 156 cases（45.64%） with hepatoprotectant treatment showed hepatic abnormality in the same period,suggesting statistical significant difference.Conclusion： Prophylactic application of hepatoprotectants can avoid or delay the occurrence of transaminase abnormality. |
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| Keywords: | Tuberculosis Pharmacotherapy Hepatoprotectants Prophylactic application |
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