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普罗帕酮治疗室性期前收缩不同疗程的疗效分析
引用本文:张金梅,张红,王爱玲.普罗帕酮治疗室性期前收缩不同疗程的疗效分析[J].中国煤炭工业医学杂志,2005,8(6):556-558.
作者姓名:张金梅  张红  王爱玲
作者单位:727000,陕西省铜川市,铜川矿务局中心医院
摘    要:目的观察普罗帕酮治疗室性期前收缩不同疗程的疗效、复发率、不良反应、心率及心电图参数的改变。方法时135例经心电图及临床确诊的室性期前收缩患者,分为长疗程组(用药3个月)76例,短疗程组(用药2周)59例。剂量从300mg/d开始,不超过600mg/d。分析普罗帕酮疗程与疗效、复发率的关系、不良反应、心率、心电图参数的改变。结果长疗程组及短疗程组有效率分别为76.32%和59.32%(P<0.05);长疗程组及短疗程组停药后随访观察1年。1~6个月、7~12个月复发率分别为10.35%、65.71%和13.79%、82.86%(P值均<0.005);同组内普罗帕酮不同剂量范围对复发率无明显影响(P>0.05),组间相同或不同剂量范围复发率差异有统计学意义(P<0.05~0.005);普罗帕酮不良反应发生率为10.37%,其中与心脏有关的占2.22%;长疗程组用药后心电图P—R间期、QRS时限延长,组内、组间比较差异均有统计学意义(P<0.01),但绝大多数为正常范围内的延长。结论普罗帕酮长疗程治疗室性期前收缩效果佳,长期观察复发率低,安全度高。因此,普罗帕酮长疗程用药可推荐为治疗室性期前收缩的有效方法之一。

关 键 词:普罗帕酮  室性期前收缩
文章编号:1007-9564(2005)06-0556-03
修稿时间:2005年3月14日

ANALYSIS OF DIFFERENT TREATMENT COURSES BY PROPATENONE ON VENTRICULAR PREMATURE BEATS
Zhang Jinmei,Zhang Hong,WANG Ailing.ANALYSIS OF DIFFERENT TREATMENT COURSES BY PROPATENONE ON VENTRICULAR PREMATURE BEATS[J].Chinese Journal of Coal Industry Medicine,2005,8(6):556-558.
Authors:Zhang Jinmei  Zhang Hong  WANG Ailing
Institution:Zhang Jinmei,Zhang Hong,Wang Ailing. Central Hospital of Tongchuan Mineral Bureau,Tongchuan 727000,China
Abstract:Objective To observe the effect on different courses, relapse rates, bad reaction, heart beat rate and ECG parameters changes. Methods 135 patients suffered from ventricular premature beats were divided into two groups according to the clinic definite diagnosis and different treatment courses by propatenone. The long course treatment group (had taken the medicine for 3 months) had 76 cases and the short one (had taken the medicine for only 2 weeks) had 59 cases. The initial dose was 300mg/d, and not more than 600mg/d. The patients were followed up for one year after the medicine taken effect. Then we analyzed the relationship between the course of treatment and its effect of propatenone on relapse rates, bad reaction, heart beat rate and ECG parametre changes. Results The effective rate in the long course treatment group was 76. 32% after treatment and that in the short course treatment was 59. 32% (P< 0. 05). The patients had been followed up for 1 - 6 months and 7 - 12 months and the relapse rates in the short course treatment group and that in the long course treatment group were 10.35%, 65.71% and 13.79%,82.86%(P<0.005). There was no significant difference of the relapse rates among differented dose ranges in the same group (P > 0.05 ) . There was significant difference between the two groups at the same or different dose range(P<0.05 - 0.005. Bad reaction of propatenone was 10.37%, of which 2.22% concerned with the heart. P - R and QRS intervals of the ECG were prolonged after the patients in the long course treatment group taken the medicine, . There was significant difference between the two groups before and after taken the medicine (P< 0. 01), and most of the intervals were prolonged within normal range. Conclusion The long course of propatenone has a better effect on ventricular premature beats. There is a lower relapse rate and the therapy is quite safe. So the long course of propatenone can be recommended as one of the effective methods for ventricular premature beats.
Keywords:propatenone  ventricular premature beat
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