Clozapine cases with fatal,toxic or therapeutic concentrations |
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Authors: | Karen Worm Birgitte Kringsholm Anni Steentoft |
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Affiliation: | (1) Institute of Forensic Chemistry, University of Copenhagen, Frederik Vs Vej 11, P.O.Box 2713, DK-2100 Copenhagen, Denmark;(2) Institute of Forensic Pathology, University of Copenhagen, Frederik Vs Vej 11, P.O.Box 2713, DK-2100 Copenhagen, Denmark |
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Abstract: | Summary The neuroleptic drug clozapine is used in the treatment of schizophrenia and is characterized by not having the extrapyrimidal side-effects usually shown by neuroleptics. Unfortunately clozapine has other side-effects, which limit its use. This study presents methods for the analysis of clozapine and desmethylclozapine in whole blood and tissue. Case histories and pathology findings are described for 3 autopsy cases with fatal concentrations of clozapine, 5 with toxic concentrations and 2 with therapeutic concentrations together with the concentrations found in a living person. |
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Keywords: | Clozapine Desmethylclozapine Whole blood Liver Concentrations |
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